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Il pentobarbital può essere somministrato per via intraperitoneale o endovenosa. Quando viene utilizzato come anestetico generale, il pentobarbital può essere somministrato in bolo (Borkowski et al., 1990) o CRI. Le soluzioni commerciali contengono comunemente glicole propilenico, che può causare dolore durante l'iniezione e tromboflebite.

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